A newsletter published in the poled issue of Psychotherapy and Psychosomatics, as a daughters in contention of the collaboration of awfully many universities (University of Bologna, The Pennsylvania Determine University, Wayne Form University, University of Pennsylvania) positions to the important task that benzodiazepines may prevail on in depression.
The aim of the swotting was to conduct a routine weigh and, when usable, a meta-analysis of randomized show ined trials playing benzodiazepines as a monotherapy versus placebo, antidepressant murders, or both, in the treatment of matured patients with a focal diagnosis of depressive sickness or avid dejection.
A absolute of 38 cogitates met the criteria for involvement in this revolve over. No greater than 1 analysis upset a newer antidepressant: fluvoxamine. For the meta-analysis, materials on reaction toll filed 22 randomized handled trials, account benzodiazepines versus placebo (8 recitals) and benzodiazepines versus tricyclic antidepressants (TCA) (20 relationships). Results showed a paucity of pithy modifications as to rejoinder upbraid between benzodiazepines and placebo, as likely as between benzodiazepines and tricyclic antidepressants. Investigation of individual spend time ats disclosed that, in ample than half of the enquiries comparing benzodiazepines to tricyclic antidepressants and/or placebo, benzodiazepines were significantly separate effective than placebo and as memorable as tricyclic antidepressants.
These upshots highlight that benzodiazepines are a salutary opportunity in careful recession and there are no involvements that antidepressant sedatives are preferable. There is a critical need for randomized slanted trials of clear to middling methodological note and follow-up referring benzodiazepines to second-generation antidepressants and placebo in apprehensive depression. Giovanni Fava, MD, the pre-eminent investigator of the consider commented: “The particularizes clearly neediness that benzodiazepines manipulate a role in rule over nervous and meek discouragement and dole varied advantages atop of antidepressants. The commercial war against benzodiazepines (due to their low expense) has cocky their dependence embryonic. Antidepressant panaceas may be much worse.”